Holding on to DNA

Holding on to peroxisomes

Yeast cells are known to actively partition organelles between the mother and bud during division. Mitochondria, for example, are subjected to both retention and ordered movement to ensure that a proper fraction of the organelles end up in each cell after cytokinesis. In the case of peroxisomes, researchers knew that a subset of the organelles moved into the bud in a myosin-dependent manner, bu...

Holding on through DNA Replication: Histone Modification or Modifier?

Histone methylation is widely believed to contribute to epigenetic inheritance by persevering through DNA replication and subsequently templating methylation of daughter chromosome regions. However, a report in this issue (Petruk et al.) suggests that chromatin association of the methytransferase complexes themselves persists through replication and re-establishes histone methylation.

Holding services to account

BACKGROUND Recently, the frequency of audit inspections of health services for people with intellectual disability (ID) in the UK has increased, from occasional inquiries to a systematic audit of all services. From 2008, a process of continuous audit 'surveillance' of specialist health services is to be introduced. Similar regimes of inspection are in place for social care services. AIM To ex...

Holding the lid on HIV.

Chemotaxis: moving forward and holding on to the past.

The ability of cells to sense external chemical cues and respond by directionally migrating towards them is a fundamental process called chemotaxis. This phenomenon is essential for many biological responses in the human body, including the invasion of neutrophils to sites of inflammation. Remarkably, many of the molecular mechanisms involved in controlling neutrophils chemotaxis arose millions...